Lab Overview

The Li Lab aims to bridge basic studies of kidney organogenesis and translational applications of stem/progenitor cell-based kidney regeneration and disease modeling, with the long-term goal of rebuilding the kidney. We achieve this by combining state-of-the-art stem cell technologies and engineering methodologies.

  • segmented nephron structure
    Formation of segmented nephron structure from expandable NPCs in chicken embryo (Image courtesy of the Li Lab)
  • Formation of vascularized glomeruli
    Formation of vascularized glomeruli upon transplantation of expandable NPCs in vivo (Image courtesy of the Li Lab)
  • Nephron organoid formation from expandable NPCs
    Nephron organoid formation from expandable NPCs on air-liquid interface (Image courtesy of the Li Lab)
  • Gene-edited human iPSC line
    Gene-edited human iPSC line with SIX2-EGFP knock-in loci (Image courtesy of the Li Lab)

  • Mouse Kidney

     Incorporation of expandable NPCs into developing mouse kidney in vivo (Image courtesy of the Li Lab)